The adjusted odds ratio for Alzheimer disease among people diagnosed with ATTR-CM was 0.65, suggesting a lower likelihood of developing the disease compared with controls. Transthyretin-mediated ...

The researchers analyzed 15 different transthyretin (TTR) gene variants in the Spanish cohort. Hereditary transthyretin-mediated amyloid cardiomyopathy (ATTR-CM) is clinically and genetically ...

Efanesoctocog alfa improves hemostasis, reduces bleeding, and enhances quality of life for patients with severe hemophilia A, including those previously excluded from trials. Efanesoctocog alfa has ...

If approved, CAM2029 could offer a self-administered alternative to intramuscular long-acting somatostatin analogs, with the potential to reduce treatment burden. The US Food and Drug Administration ...

Among the 175 patients without atrial fibrillation at baseline, 41% developed new-onset atrial fibrillation over a median follow-up of 2 years. Over 50% of patients with transthyretin-mediated amyloid ...

Fenebrutinib demonstrated noninferiority to ocrelizumab in patients with PPMS, a population with limited treatment options. Genentech has reported that fenebrutinib reduced relapse rates in relapsing ...

No matter if I ate healthy, went to yoga, drank water, and did all the necessary things, the weight started to pile on. I am someone who has struggled with my weight my entire life. I’ve done the ...

Multiomics integration identified 31 candidate genes that may underlie early decitabine resistance and suggest sensitization strategies. To enable comparable cytotoxicity, optimized conditions were ...

The majority (79%) of cardiac amyloidosis cases were responsible for sudden cardiac death. Cardiac amyloidosis can be associated with sudden cardiac death and is often undiagnosed during a person’s ...

Statin treatment reduces the expression of TOMM40 and TOMM22, thereby impairing mitochondrial function. Statins effectively lower plasma low-density lipoprotein cholesterol levels, but they also ...

Biochemical response rates were sustained through week 182 in patients with PBC treated with elafibranor, and the proportion of patients with normal alkaline phosphatase levels remained consistent.

The researchers reported that Scheuer stage score increased significantly with histological stage and GLOBE score. The GLOBE score of patients with primary biliary cholangitis (PBC) before treatment ...