Cancer cells rely on powerful genetic switches to keep growth genes running at full speed, but that intense activity can damage their own DNA. The resulting breaks are repeatedly repaired, sometimes ...

Determining how muscle stem cells use TRF2 differently from cells in other tissues could eventually help researchers stimulate tissue repair without also raising the risk of cancer. Mourkioti and her ...

A baby can inherit one healthy copy of TBX5 and still develop serious heart defects if the other copy does not work. That genetic imbalance is one cause of congenital heart disease, the most common ...

A protein best known for protecting the ends of chromosomes also helps muscle stem cells preserve their identity and repair damaged tissue, according to a new study from researchers at the Perelman ...

Every time a cell divides, it must accurately copy and distribute its DNA between two new cells. However, in some cases, chromosomes do not fully separate, leaving behind thin strands of DNA known as ...

Our DNA is under constant threat. Chemicals, radiation and the everyday errors of cell division all damage it, and if left ...

Aging muscles may not lose the signals needed for repair. Instead, those signals may remain in place but become chemically ...