Israel launched powerful airstrikes in Damascus on Wednesday, blowing up part of the defence ministry and hitting near the presidential palace as it vowed to destroy government forces attacking Druze in southern Syria and demanded they withdraw.

The Israel Defense Forces (IDF) said the Damascus headquarters served as a command center for deploying regime forces to Suwayda, a southern Syrian region gripped by days of deadly clashes between government troops, Druze militias, and Bedouin groups.

The United States said it did not support recent Israeli strikes on Syria and had made clear its displeasure, while Syrian leader Ahmed al-Sharaa accused Israel of trying to fracture his country.

"If Israel feels that a certain leader...is an evident threat to its national security, it will operate," a former Israeli envoy told Newsweek.

Israel’s demand for a demilitarized zone in southern Syria and its promise to protect the Druze minority are putting it in deepening conflict with the new regime in Damascus.

Hundreds of Druze from Israel pushed across the border in solidarity with their Syrian cousins they feared were under attack. Many then met relatives they had never seen before.

Secretary of State Marco Rubio says IDF strike on Damascus ‘likely a misunderstanding’ after fighting erupted in Syria.