A marathon Sunday of Week 5 produced plenty of winners and losers, with the 49ers and Bills among the teams sparking concerns ...

With the San Francisco 49ers (2-3) and the Seattle Seahawks (3-2) squaring off on Oct. 10 at Lumen Field, Brock Purdy and ...

It was a good day for the future of the Las Vegas Raiders. Not because of what happened in their matchup against the Denver ...

Here’s what fans and analysts were saying on Twitter after the 49ers dropped a shocking loss to the Cardinals in Week 5.

The 49ers just blew another 10-point fourth quarter lead and lost 24-23 to the Arizona Cardinals. Now the 49ers are 2-3. Here ...

The defense wilted in the heat, the offense couldn’t finish drives or protect the ball and the San Francisco 49ers blew ...

San Francisco 49ers running back Christian McCaffrey won't return in Week 6, but will likely make his long-awaited comeback ...

The 49ers are a 7.5-point favorite over the Cardinals in NFL Week 5 odds for the game, courtesy of BetMGM Sportsbook. San ...

The San Francisco 49ers have officially ruled out strong safety Talanoa Hufanga with a wrist injury he suffered early in Week ...

The 49ers' biggest issue was something that's plagued them all season: They had six trips to the red zone and scored just one ...

Kyle Juszczyk took a shot at Niner beat reporter Grant Cohn, implying that a married man is gay. Whether Juszczyk was saying ...

Kyler Murray had a long touchdown run in the first quarter and rallied Arizona with two fourth-quarter scoring drives in the ...