A division as difficult as the NFC West has become cannot be won in Week 1. But winning or losing the first divisional matchup of the season can go a long way towards hopes of a division title being made or broken.

Preview the Seattle Seahawks' NFL Week 1 matchup with the 49ers, including live stream, TV channel, odds, and game information.

Learn which TV channel or how to live stream the NFL Week 1 Seattle Seahawks and San Francisco 49ers game, Sunday, Sept. 7.

The San Francisco 49ers, led by quarterback Brock Purdy, face the Seattle Seahawks , led by quarterback Sam Darnold, on Sunday, Sept. 7, 2025 (9/7/25) at Lumen Field in Seattle, Washington.

Time, TV, radio, live stream, and everything else you need to know to follow the Week 2 action vs. the Steelers at Acrisure Stadium.

The San Francisco 49ers (0-0) and the Seattle Seahawks (0-0) play on Sunday, September 7, 2025 at Lumen Field in a battle of NFC West foes. Date: Sept. 7 Time: 4:05 p.m. ET

Sunday, September 7thTime: 4:05 p.m. ETTV Channel: FOXLive Stream: fuboTV (watch for free) The San Francisco 49ers

The Eagles are always looking to add talent to the roster, and after getting lukewarm pressure on Dak Prescott, the team is adding Za'Darius Smith. Philadelphia agree

The NFL season continues with the Seattle Seahawks hosting the San Francisco 49ers Sunday. Start time, where to watch, streaming and NFL schedule.