A team of chemists has unveiled a novel method to simplify the synthesis of piperidines, a key structural component in many pharmaceuticals. The study combines biocatalytic carbon-hydrogen oxidation ...

Postdoctoral researcher Urmila Sehrawat discusses her work at Memorial Sloan Kettering Cancer Center on translational machinery and novel cancer therapeutics.

Merck researchers developed a highly sustainable way to synthesize the macrocyclic peptide drug enlicitide, increasing ...

A University of Texas at Dallas chemist and his colleagues have developed a new chemical reaction that will allow researchers to synthesize selectively the left-handed or right-handed versions of ...

“What this paper illustrates is the incredible power of biocatalysis to manufacture incredibly complex macrocyclic peptides,” says David A. Thaisrivongs, who leads the biocatalysis team in Merck & Co.

When chemists design drug candidates, shape matters enormously. Many active pharmaceutical ingredients contain branched carbon structures—points where the molecular chain forks in a specific direction ...

Scientists have leveraged fundamental features of chemical building blocks to transform chemical reaction analysis from minutes to milliseconds. The development of molecules to study and treat disease ...

Hans Renata and Kenta Yokoi in Renata’s lab at Rice (Credit: Alex Becker/Rice University). A team of chemists from Scripps Research and Rice University has unveiled a novel method to simplify the ...