The nuclear pore complex (NPC) is a large multiprotein assembly embedded within the nuclear envelope of eukaryotic cells. Comprising around thirty distinct nucleoporins arranged into structural ...

Enterovirus D68, a cause of acute flaccid myelitis, disrupts the composition and function of the nuclear pore complex primarily through its 2A protease, which is also toxic to motor neurons.

In situ model of the nuclear pore complex transport barrier: Tethered within the pore are highly dynamic protein threads termed FG Nups (green). Under physiological conditions, cargo-carrying ...

Super-resolution microscopy has promoted the development of cell biology, but imaging proteins with low copy numbers in cellular structures remains challenging. The limited number of designated ...

Proteins are most well-known for their intricate structures. The α-helices and β-sheets that form from interactions between sidechains create distinct shapes that, along with the specific amino acid ...