Cryptococcal meningitis is a leading cause of human immunodeficiency virus (HIV)–related death in sub-Saharan Africa. Whether a treatment regimen that includes a single high dose of liposomal ...
The mechanism for a critical but highly toxic antifungal is revealed in high resolution. Self-assembled Amphotericin B sponges rapidly extract sterols from cells. This atomic level understanding ...
Charge pairing between neighboring amphotericin B molecules inserted into the membrane is believed to significantly stabilize supramolecular channel architecture. Now the synthetic “knockout” of a ...
Atomic structure of antifungal drug confirms unusual mechanism, opens door to less-toxic derivatives
Advanced molecular imaging technology has now mapped the structure of a drug widely used to treat fungal infections but whose workings have mystified researchers and physicians for nearly 70 years.
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