Sep 7, 2025; Seattle, Washington, USA; San Francisco 49ers quarterback Brock Purdy (13) reacts following a failed third down play against the Seattle Seahawks during the fourth quarter at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images / Joe Nicholson-Imagn Images

The 49ers will not just be any pushover team. They’ve got a solid roster with guys who will step in and fill the voids like former first-round draft pick QB Mac Jones. He is the 49ers’ projected starter against the Saints.

The Arizona Cardinals picked up the win in Week 1 over the New Orleans Saints to start the 2025 season 1-0. They will look to build off that success in the coming weeks, especially with two of their next three matchups being NFC West rivals.

The Arizona Cardinals and San Francisco 49ers won't see each other until Week 3 - though a massive name will now officially be absent in the NFC West

This past week, players Nos. 11-20 were brought to light and the Cardinals will face player No. 16 twice, as he is a division rival. San Francisco 49ers linebacker Fred Warner came in at No. 16. He was No. 11 in 2024. Pittsburgh Steelers linebacker Patrick Queen said that Warner was the best linebacker in the league in 2024.

Massive injury news announced by ESPN’s Adam Schefter that will indirectly effect the Arizona Cardinals. Schefter announced on X Tuesday Morning that San Francisco 49ers tight end George Kittle will be placed on injury reserve due to an hamstring injury,

The Arizona Cardinals placed safety Joey Blount on injured reserve with a neck injury on Wednesday, the team announced.

The Cardinals' defense is rostered in 55% of ESPN leagues and despite being ranked 17th by ESPN Fantasy heading into the season, it's the third-ranked defense in Week 1. A lot of that has to do with the Saints offense and unproven QB Spencer Rattler. Another reason Williams is high on Arizona is because of its ability to rush the passer.