New research sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human cells. The study demonstrates how these proteins ...

Researchers have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and premature aging. Researchers at ...

Cancer research, drug safety testing and aging biology may all gain a major boost from a new fluorescent sensor developed at Utrecht University. This new tool allows scientists to watch DNA damage and ...

Cells are constantly subjected to DNA damage from a range of internal and environmental sources. It is estimated that cells can experience as many as 100,000 DNA lesions per day. One of the most ...

DNA polymerase theta (Pol θ) orchestrates a distinct, error-prone route of double-strand break (DSB) repair known as microhomology-mediated end joining (MMEJ) or theta-mediated end joining (TMEJ).

Oocyte quality is defined by the capacity of a female gamete to complete meiosis, support fertilisation and sustain early embryonic development. Throughout the prolonged arrest in prophase of meiosis ...