A cell copies all six billion letters of its DNA, gears up to split, and then simply… doesn’t. It sits there, swollen with ...

It's tricky to make an exact copy of yourself. Or at least it is for cells undergoing mitosis, where cells replicate ...

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

Scientists have uncovered a surprising twist in how cells behave when division goes wrong. Sometimes a cell successfully copies its DNA but fails to split into two, leaving it with double the genetic ...

Eukaryotic chromosomes replicate from multiple discrete loci termed origins of replication. These sites are first recognised by the origin recognition complex (ORC), which, together with Cdc6 and Cdt1 ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

For decades, oncologists have watched a frustrating pattern repeat itself. Tumors fueled by the MYC protein, one of the most ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

How much of our genome really matters? Some argue that because most of our DNA is active, it must be doing something important. Others say even random DNA would be highly active. This has now been put ...

When it comes to cancer, tumor suppressor genes are usually thought of as the "good guys." These genes make proteins that ...