Copy number alterations (CNA) are acquired during the evolution of cancers from their early stage to metastatic stage. This study aims at analysing the clinical value of the identified ...

The allele-specific DNA copy number profile of a tumor is a window into its past history and its future evolutionary potential 1,2,3. In general, we may consider a copy number profile as the ...

Using whole genome sequencing, copy number signatures were successful in predicting both the presence of chromothripsis and clinical outcomes in patients with newly diagnosed multiple myeloma (MM).

Comparative genomic hybridization (CGH) was developed to identify pathogenic DNA copy-number changes (e.g., duplications, deletions) on a genome-wide scale, and to map these changes to genomic ...

The use of cell-free DNA (cfDNA) obtained from maternal plasma to perform noninvasive prenatal screening has been rapidly integrated into the care of pregnant women who are at high risk for fetal ...

Parents' Experiences With and Preferences for Receiving Information About Tumor Genomic Sequencing: Findings From a Qualitative Study and Implications for Practice For a 2-year overall survival end ...

Young, Empowered and Strong: A Web-Based Education and Supportive Care Intervention for Young Women With Breast Cancer Across the Care Continuum To overcome these challenges, we have developed a ...

When cancer spreads from a primary tumor to new sites throughout the body, it undergoes changes that increase its genetic complexity. A new study from researchers at Memorial Sloan Kettering Cancer ...

Using SNP-CGH to Profile for Amplifications, Duplications, and Deletions The beginnings of personalized medicine have been forged by recent advances in SNP genotyping technologies. It is now possible ...

Determining the number of copies of a double stranded DNA template (be it genomic DNA, plasmid or an amplified fragment) is essential for many genetic quantification applications in research and ...