CHICAGO -- Intracerebroventricular (ICV) delivery of bivalent CAR T-cells targeting EGFR and IL13Rα2 was feasible and appeared safe in patients with recurrent glioblastoma (GBM) in a phase I study ...
Achieving widespread delivery of pharmacological agents beyond the blood-brain barrier (BBB) remains a formidable challenge in preclinical and clinical research. Here we quantitatively evaluate and ...
Intrathecal delivery of autologous culture-expanded adipose tissue-derived mesenchymal stem cells (AD-MSC) could be utilized to treat traumatic spinal cord injury (SCI). This Phase I trial ...
Leptomeningeal metastases (LM) occur when cancerous cells metastasize or spread to the leptomeninges, cerebral spinal fluid (CSF), or both. The meninges are thin layers of tissue surrounding and ...
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